Connection between periodontal disease and chronic kidney disease: A literature review

Diogo Marques Sapata, Giovani de Oliveira Corrêa, Mario dos ANJOS Neto-Filho, Fabiano Carlos Marson, Cléverson de OLIVEIRA E Silva

Abstract / Introduction: The association between periodontal disease (PD) and chronic kidney disease (CKD) is bidirectional, as individuals with CKD may have oral manifestations, and PD may develop as a complicating factor of CKD. The systemic inflammatory response found in periodontal patients may have a synergistic effect on the chronic inflammation found in CKD. Objective: To review the literature to find evidence of the importance of the association between these two conditions. Methods: A PubMed search of studies published between 2003 and 2013 was conducted to retrieve clinical trials and systematic reviews. Results: Six clinical trials and one systematic review met the established criteria. Clinical trials used different approaches for the association between PD and CKD. Studies investigating the association between PD and CKD used a crossover design, evaluation of the oral manifestations in patients with CKD, and analysis of the effect of periodontal treatment on markers of renal disease. Conclusion: In addition to systemic functions, CKD also affects oral health, particularly causing periodontal tissues. Moreover, PD may affect kidney functions and lead to complications in individuals with CKD.

Keywords: Chronic renal insufficiency. Periodontitis. Renal dialysis.

How to cite: Sapata DM, Corrêa GO, Anjos Neto-Filho M, Marson FC, Oliveira e Silva C. Connection between periodontal disease and chronic kidney disease: A literature review. Dental Press Implantol. 2014 Jan-Mar;8(1):81-5.

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