Genetic polymorphism and failure of dental implants: a pilot study

Camila Epitácio Cravo Teixeira, Tibério César Uchôa Matheus, Paulo Roberto Eleutério de Souza, Nikos Donos, Renata Cimões

Objective / To investigate the relationship between genetic polymorphisms related to cytokines in bone remodeling osteoprotegerin (OPG) and receptor activator of nuclear factor κB ligand (RANKL). It also aims to relate the presence of polymorphisms in OPG and RANKL with clinical failure of dental implants over time and to determine which combinations of polymorphisms of OPG and RANKL are associated with failure of dental implants. / Methods / Twenty patients of both sexes, over eighteen years, rehabilitated with thirty-four dental implants were evaluated during 24 months. After clinical and radiographic examination, the patients were included in a failure group if one or more of the following criteria were fulilled: mobility; persistent subjective complaints; recurrent peri-implantitis infection with suppuration; continuous radiolucency around the implant; probing depth ≥ 5 mm and bleeding on probing. Peripheral blood was collected for analysis of cytokine polymorphisms of OPG and RANKL by polymerase chain reaction (PCR). / Results / here were no statistically signiicant diferences between the failure group of implants in relation to genotype OPG and RANKL./ Conclusion / he polymorphisms of OPG and RANKL did not inluence failure of dental implants in the investigated sample.

Keywords: Dental implants. Genetic polymorphism. Osteoprotererin. RANK-Ligand.

How to cite: Teixeira CEC, Matheus TCU, Souza PRE, Donos N, Cimões R. Genetic polymorphism and failure of dental implants: a pilot study. Dental Press Implantol. 2014 Oct-Dec;8(4):68-78. doi: http://dx.doi.org/10.14436/2237-650X.8.4.068-078.oar

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