Serological profile of IgG and IgM in patients submitted: contribution for the etiopathogenesis of dental resorption

Lídia Izabel Thomé SANCHEZ, Mirian Marubayashi HIDALGO, Eiko Nakagawa ITANO, Alberto CONSOLARO

Before orthodontic treatment, 10 individuals were submitted to blood collection followed by sera analysis. After orthodontic appliance placement, 4 other blood collections were made within a 6-month period. Characterizing the serological proile of speciic IgG and IgM of human dentinal extract or its fraction, allowed correlation to radiographic indings. Sera were obtained through 15mL of venous blood, collected from orthodontic patients. The collections took place at 5 different intervals: before orthodontic appliance placement, 15 days, 1, 3 and 6 months after. Upper incisors periapical examinations of the Experimental Group were taken before treatment, 3, 6 months after and posttreatment. The results were compared to a Control Group consisted of 10 healthy individuals who had never undergone any orthodontic treatment. The Control Group had the upper incisors radiographed and blood collected once. Dentinal protein extract was obtained through wear and processing of molar dentin. Human dentinal extract was fractioned and the subunits collected by time interval with HPLC. Based on previous literature, the results allowed us to conclude that it is possible to identify dental resorption through serological proile of orthodontic patients, even before any radiographic evidence of resorption can be found.

Keywords: IgG. IgM. Human dentinal extract. Root resorption. Dental resorption. Orthodontic treatment. Dentin.

Monday, April 29, 2024 09:01