Alveolar bone regeneration in rats after grafting of anorganic bovine bone and thick synthetic bioceramic

Roberta D. Garcia, Roberto B. Garcia, Talita Tartari, Marco Antonio H. Duarte, Ivaldo G. de Moraes, Clovis M. Bramante

Introduction: It remains uncertain whether the use of biomaterial in apical surgeries facilitates or induces bone regeneration. This study comparatively analyzed the effects of socket filling with anorganic bovine medullary bone and dense synthetic bioceramic on bone regeneration in 48 rats. Methods: Forty-eight Wistar albino rats were randomly divided into three groups which had the socket filled after dental extraction as follows: GI (n = 12) blood clot (control); GII (n = 18) anorganic bovine bone; GIII (n = 18) dense synthetic bioceramic. Specimens were harvested at 7, 15 and 30 days post-surgery. Quantitative microscopic analyses of inflammatory infiltration, fibroblastic density, angioblastic density, and bone neoformation were performed. Data were subjected to Kruskal–Wallis test (α < 0.05) to detect differences between groups within the same time interval. Results: Although some differences were detected between experimental and control groups for inflammatory infiltrate and angioblastic density within 7 days, and bone formation in 15 days, the process of repair was similar for all groups within 30 days. Conclusions: There was no difference between the two types of material both of which did not delay the process of bone regeneration. Should they be used in apical surgery, they may act as osteoconductive and osteofilling material in large bone defects.

Keywords: Biocompatible material. Bone regeneration. Guided tissue regeneration. Material testing. Healing.

How to cite: Garcia RD, Garcia RB, Tartari T, Duarte MAH, Moraes IG, Bramante CM. Alveolar bone regeneration in rats after grafting of anorganic bovine bone and thick synthetic bioceramic. Dental Press Endod. 2014 Sept-Dec;4(3):28-33. DOI: http://dx.doi.org/10.14436/2178-3713.4.3.028-033.oar

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