Clinical and microbiological evaluation of the systemic use of doxycycline as an adjunct to basic periodontal therapy in the treatment of diabetes type 2 individuals with chronic periodontal disease

Priscilla do Monte Ribeiro Busato, Gisele Toyama, Fernanda Colet, Taline Karin Vendrame, Francielly Andressa Felipetti, Claudia Camila Peruzzo Lopes, Nereida Gioppo, Carlos Augusto Nassar, Patricia Oehlmeyer Nassar

Abstract: Doxycycline is a derivative of tetracycline antibiotics, with broad spectrum, effective against most periodontal pathogens, by achieving concentrations in the gingival crevicular fluid 7 to 10 times the serum level, reducing the signs and symptoms of local periodontal disease. Objectives: The aim of this study was to determine the clinical parameters, as well as a description of the types of G+ and G- microorganisms in patients with type 2 diabetes mellitus undergoing Basic Periodontal Therapy with or without the use of antimicrobials, after the total period of 180 days. Methods: 23 patients were selected and divided into two groups: Group 1 – controlled mechanical + basic periodontal treatment; Group 2 – controlled mechanical + basic periodontal treatment + Doxycycline 100 mg orally for 14 days. Results: The results showed an improvement in all clinical periodontal parameters evaluated as well as the levels of glycated hemoglobin in both treated groups after 180 days. In Group 2, there was a greater improvement in gingival index of glycated hemoglobin, as well as a smaller amount of G- colonies at the end of the experimental period, in relation to Group 1. Conclusion: It is suggested that the systemic use of doxycycline associated with basic periodontal therapy showed clinical and microbiological results beneficial and superior to basic periodontal therapy only, in type 2 diabetic subjects with chronic periodontitis.

Keywords: Diabetes Mellitus. Periodontitis. Doxycycline.

How to cite: Busato PMR, Toyama G, Colet F, Vendrame TK, Felipetti FA, Lopes CCP, et al.. Clinical and microbiological evaluation of the systemic use of doxycycline as an adjunct to basic periodontal therapy in the treatment of diabetes type 2 individuals with chronic periodontal disease. J Clin Dent Res. 2017 Apr-June;14(2):40-50. DOI: https://doi.org/10.14436/2447-911x.14.2.040-050.oar

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